반응 #1164100

반응 방정식

benzene

2-allylaminoacetaldehyde

benzene

5-t-butyl-1,3,4-thiadiazol-2-yl isocyanate

→

2-[1-allyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde

용매

diethyl ether pentane

반응 조건

후처리

1. 1
   기타equipped with a mechanical stirrer
2. 2
   온도reflux condenser
3. 3
   온도The reaction mixture was heated
4. 4
   기타to yield an oil
5. 5
   여과was filtered through diatomaceous earth

실험 절차

A mixture of 5-t-butyl-1,3,4-thiadiazol-2-yl isocyanate dimer (8.7 grams), the diethyl acetate of 2-allylaminoacetaldehyde (8.0 grams) and benzene (30 ml) was charged into a glass reaction flask equipped with a mechanical stirrer and reflux condenser. The reaction mixture was heated with stirring for a period of about 15 minutes. After this time the reaction mixture was stripped of benzene to yield an oil. The oil was dissolved in a diethyl ether-pentane mixture and was filtered through diatomaceous earth. The filtrate was stripped of solvent to yield the desired product the diethyl acetal of 2-[1-allyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde as a dark oil.

출처