반응 #11640

반응 방정식

3-hydroxymethylene-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one

4-(3-piperidin-1-yl-propoxy)-phenylamine

→

compound

6-(3-Methoxy-phenyl)-3-{[4-(3-piperidin-1-yl-propoxy)-phenylamino]-methylene}-1,3-dihydro-indol-2-one

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The named compound is prepared
2. 2
   기타solvent evaporation in vacuo, trituration
3. 3
   여과with isopropanol and filtration the reaction

실험 절차

The named compound is prepared by refluxing 0.020 gms E & Z 3-hydroxymethylene-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one (see example 268) with 0.0375 gms 4-(3-piperidin-1-yl-propoxy)-phenylamine (used in the preparation of Example 218) in tetrahydrofuran (0.33 mL) for 36 h. Following cooling to room temperature, solvent evaporation in vacuo, trituration with isopropanol and filtration the reaction yields the named compound as a solid in the amount of 16.8 mg.

출처