반응 #1161330

반응 방정식

6-chloro-N-(2,6-dimethylphenyl)-3-pyridinecarboxamide

methylamine

→

desired title product

수율 57.2%

6-(Methylamino)-N-(2,6-dimethylphenyl)-3-pyridinecarboxamide

수율 57.2%

용매

ethanol

반응 조건

후처리

1. 1
   기타solvents were removed under reduced pressure
2. 2
   기타the product was recrystallized from ethanol

실험 절차

A solution of 5 g of 6-chloro-N-(2,6-dimethylphenyl)-3-pyridinecarboxamide and 6 g of methylamine (from a 40% aqueous solution) in 100 ml of ethanol were heated at 250° C. in a closed reaction vessel for 72 hours. The reaction mixture was cooled to room temperature, solvents were removed under reduced pressure, and the product was recrystallized from ethanol, providing 2.8 g of the desired title product, m.p. 207°-209° C.

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