반응 #1161229

반응 방정식

Bromine

5-acetyl-2,2-dimethyl-1,3-benzodioxole

water

→

5-(2-Bromoacetyl)-2,2-dimethyl-1,3-benzodioxole

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   workup.WAITthe mixture is left
2. 2
   기타The organic phase is separated off after settling
3. 3
   건조dried over anhydrous magnesium sulphate
4. 4
   여과filtered
5. 5
   기타evaporated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa)

실험 절차

Bromine (1.5 cc) is added in the course of 5 minutes at a temperature in the region of 20° C. to a stirred solution of 5-acetyl-2,2-dimethyl-1,3-benzodioxole (5.8 g) in carbon tetrachloride (100 cc), and the mixture is left with stirring for 15 hours at the same temperature. The reaction mixture is taken up with water (150 cc). The organic phase is separated off after settling has taken place, dried over anhydrous magnesium sulphate, filtered and evaporated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa). 5-(2-Bromoacetyl)-2,2-dimethyl-1,3-benzodioxole (7.1 g) is obtained, and is used in the crude state in the subsequent syntheses.

출처