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α-methylthioacetophenone

5-(2-bromoacetyl)-2,2-dimethyl-1,3-benzodioxole

Sodium methanethiolate

→

2,2-Dimethyl-5-[2-(methylthio)acetyl]-1,3-benzodioxole

용매

methanol

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후처리

1. 1
   workup.WAITthe mixture is left

실험 절차

The procedure is as in Example 4 for the preparation of α-methylthioacetophenone, starting with a stirred solution of 5-(2-bromoacetyl)-2,2-dimethyl-1,3-benzodioxole (14.9 g) in methanol (150 cc). Sodium methanethiolate (3.8 g) is added in the course of 5 minutes at a temperature in the region of 20° C., and the mixture is left with stirring for 15 hours at the same temperature. 2,2-Dimethyl-5-[2-(methylthio)acetyl]-1,3-benzodioxole (11 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.

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