반응 #1161

반응 방정식

acetic acid

KMnO4

4-(methylthio)acetophenone

sodium sulfite

→

4-(methylsulfonyl)acetophenone

용매

water

water

반응 조건

후처리

1. 1
   기타to return to room temperature
2. 2
   workup.WAITThis is left
3. 3
   기타The solid obtained
4. 4
   여과is filtered off
5. 5
   세척washed copiously with water
6. 6
   기타recrystallized from 95% ethanol

실험 절차

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

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