반응 #1158

반응 방정식

(E)-3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]-2-propen-1-ol

→

3-[5-(5-methylphenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol

수율 93.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타followed by catalytic reduction at room temperature and under an atmospheric pressure of 1 atm
2. 2
   여과After the catalyst was filtered off
3. 3
   농축the filtrate was concentrated

실험 절차

To a solution of (E)-3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]-2-propen-1-ol (2.00 g) in tetrahydrofuran (100 ml), palladium-carbon (5%, 0.30 g) was added, followed by catalytic reduction at room temperature and under an atmospheric pressure of 1 atm. After the catalyst was filtered off, the filtrate was concentrated to yield 3-[5-(5-methylphenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol (yield 93%), which was then recrystallized from acetone-isopropyl ether to yield colorless prisms having a melting point of 101° to 102° C.

출처