반응 #1156274

반응 방정식

methyl (R)-2-(3,5-dichlorophenyl)-2-hydroxyethanoate

tert-butyidimethylsilyl chloride

imidazole

→

oil

수율 96.6%

Methyl (R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(3,5-dichlorophenyl)ethanoate

수율 96.6%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타Volatiles were then removed under vacuum
2. 2
   기타the residue was chromatographed on silica gel
3. 3
   세척eluting with hexanelethyl acetate (20:1) The title compound

실험 절차

A solution of methyl (R)-2-(3,5-dichlorophenyl)-2-hydroxyethanoate (10.485 g), tert-butyidimethylsilyl chloride (8.07 g), and imidazole (3.64 g) in N,N-dimethylformamide (50 mL) was stirred under nitrogen for 18 h. Volatiles were then removed under vacuum and the residue was chromatographed on silica gel, eluting with hexanelethyl acetate (20:1) The title compound was obtained as a colorless oil (15.05 g).

출처