반응 #11561

반응 방정식

Methyl iodide

1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea

→

titled compound

수율 96.0%

4-[3-[3-[2-(1-Adamantyl)ethyl]-3-pentylureido]propyl]-1-methylpyridinium iodide

수율 96.0%

용매

acetone

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure from the reaction mixture
2. 2
   여과the precipitated crystals were filtered off with ethyl acetate

실험 절차

Methyl iodide (90 μl, 1.5 mmol) was added to a solution of 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-1) (0.30 g, 0.73 mmol) in acetone (1.5 ml) at room temperature, and the mixture was stirred overnight. The solvent was evaporated under reduced pressure from the reaction mixture, and the precipitated crystals were filtered off with ethyl acetate to give 389 mg (96%) of the titled compound.

출처