반응 #1155046

반응 방정식

12-bromo-2,10-dichloro-12H-5,7-dioxa-dibenzo[a,d]cyclooctene

2-bromoethanol

potassium carbonate

→

12-(2-bromo-ethoxy)-2,10-dichloro-12H-5,7-dioxa-dibenzo[a,d]cyclooctene

수율 82.4%

용매

dichloromethane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONadded water (25 mL)
3. 3
   추출the product extracted with ethyl acetate (3×25 mL)
4. 4
   건조The combined organic phases were dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated

실험 절차

A mixture of 12-bromo-2,10-dichloro-12H-5,7-dioxa-dibenzo[a,d]cyclooctene (900 mg, 2.5 mmol), 2-bromoethanol (3.75 g, 30 mmol) and potassium carbonate (1.0 g, 7.2 mmol) in dichloromethane (10 mL) was heated at 120 ° C. for 4 h. The reaction mixture was concentrated in vacuo, added water (25 mL) and the product extracted with ethyl acetate (3×25 mL). The combined organic phases were dried (MgSO4), filtered and evaporated to give 832 mg (82%) of 12-(2-bromo-ethoxy)-2,10-dichloro-12H-5,7-dioxa-dibenzo[a,d]cyclooctene.

출처