반응 #11523

반응 방정식

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   추출extracted twice with ethyl acetate
3. 3
   세척The combined solvent phase was washed twice with brine
4. 4
   건조dried (magnesium sulphate)
5. 5
   기타evaporated

실험 절차

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

출처