반응 #11511

반응 방정식

Methyl 4-aminobenzoate

iodine

→

Methyl 4-amino-3-iodobenzoate

용매

ethanol

반응 조건

후처리

1. 1
   여과filtered over Celite
2. 2
   기타the filtrate was evaporated to dryness under reduced pressure
3. 3
   기타The residue was chromatographed on silica gel (230–400 mesh)
4. 4
   세척eluted with 1% ethyl acetate in hexane
5. 5
   기타to give 35 g (63%)

실험 절차

Methyl 4-aminobenzoate (30.23 g, 200 mmol) was added to a mixture of iodine (60.91 g, 240 mmol) and silver sulfate (81.07 g, 260 mmol) in 1 L of ethanol at room temperature. The mixture was stirred at room temperature for 18 hours, filtered over Celite and the filtrate was evaporated to dryness under reduced pressure. The residue was chromatographed on silica gel (230–400 mesh) and eluted with 1% ethyl acetate in hexane to give 35 g (63%).

출처