반응 #11500

반응 방정식

water

4-hydroxybenzoic acid

potassium carbonate

2-propyloxyethyl chloride

→

title compound

수율 105.6%

4-(2-Propyloxyethoxy)benzoic acid

수율 105.6%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGstirred at 80° C. for 8 hours
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   세척The organic layer was washed with water
4. 4
   건조a saturated aqueous solution of sodium chloride, successively, dried
5. 5
   농축concentrated under reduced pressure

실험 절차

To a solution of 4-hydroxybenzoic acid (3.04 g) and anhydrous potassium carbonate (5.52 g) in N,N-dimethylformamide (20 ml) was added 2-propyloxyethyl chloride (2.94 g), and the mixture was stirred at room temperature overnight, and then stirred at 80° C. for 8 hours. To a reaction solution was added water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, successively, dried and concentrated under reduced pressure to give the title compound (5.21 g; crude).

출처