반응 #1147201

반응 방정식

N,N′-bis(tert-butoxycarbonyl)-N″-(2-(1,3-dioxolan-2-yl)-5-(4-methoxylpyridin-2-yl)phenyl)guanidine

hydrochloric acid

→

2-amino-7-(4-methoxypyridin-2-yl)quinazoline dihydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   workup.ADDITIONTo the residue was added 5% ethanol in ethyl acetate (50 ml)
3. 3
   여과the precipitate was collected by filtration
4. 4
   기타dried under reduced pressure

실험 절차

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(2-(1,3-dioxolan-2-yl)-5-(4-methoxylpyridin-2-yl)phenyl)guanidine (200 mg) in ethanol (2 ml) was added hydrochloric acid (36%, 1 ml), and the mixture was stirred for 18 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 2-amino-7-(4-methoxypyridin-2-yl)quinazoline dihydrochloride (89 mg).

출처