반응 #1147157

반응 방정식

4-(4-methoxypyridin-2-yl)-2-nitrotoluene

→

5-(4-methoxypyridin-2-yl)-2-methylaniline

수율 96.5%

용매

tetrahydrofuran

ethanol

반응 조건

후처리

1. 1
   여과The catalyst was filtered off
2. 2
   기타the filtrate was evaporated under reduced pressure

실험 절차

A suspension of 4-(4-methoxypyridin-2-yl)-2-nitrotoluene (300 mg) in tetrahydrofuran (3 ml) and ethanol (3 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 150 mg) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 5-(4-methoxypyridin-2-yl)-2-methylaniline (254 mg).

출처