반응 #1147149

반응 방정식

1-chloro-4-(4-methoxypyridin-2-yl)-2-nitrobenzene

ammonium chloride

→

2-chloro-5-(4-methoxypyridin-2-yl)aniline

수율 98.1%

용매

ethanol

water

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 3 hours
2. 2
   여과The mixture was filtered
3. 3
   기타the filtrate was evaporated under reduced pressure
4. 4
   workup.ADDITIONTo the residue were added ethyl acetate and water
5. 5
   세척The separated organic layer was washed with brine
6. 6
   건조dried over magnesium sulfate
7. 7
   기타evaporated under reduced pressure

실험 절차

To a suspension of 1-chloro-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (200 mg) in ethanol (6 ml) and water (0.6 ml) were added iron powder (206 mg) and ammonium chloride (28 mg), and the mixture was refluxed for 3 hours. The mixture was filtered, and the filtrate was evaporated under reduced pressure. To the residue were added ethyl acetate and water. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated under reduced pressure to give 2-chloro-5-(4-methoxypyridin-2-yl)aniline (174 mg).

출처