반응 #11466

반응 방정식

6-Chloro-4-hydroxy-5-methyl-1H-pyridin-2-one hydrochloride

Nitric acid

→

6-chloro-4-hydroxy-5-methyl-3-nitro-1H-pyridin-2-one

용매

sulfuric acid

반응 조건

후처리

1. 1
   온도while cooling in an ice bath
2. 2
   기타The resulting precipitate was isolated by filtration
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

6-Chloro-4-hydroxy-5-methyl-1H-pyridin-2-one hydrochloride (64 g) was dissolved in sulfuric acid (325 mL) while cooling in an ice bath. Nitric acid was added dropwise over a period of 90 minutes. The reaction mixture was allowed to stir for an additional 30 minutes and then it was poured into ice water (2 L). The resulting precipitate was isolated by filtration, washed with water and then dried to provide 42.5 g of 6-chloro-4-hydroxy-5-methyl-3-nitro-1H-pyridin-2-one as a light yellow solid.

출처