반응 #1144440

반응 방정식

acetone

2,4,6-trichloro-1,3,5-triazine

NaOH

tert-butylamine

→

2-tert-butylamino-4,6-dichloro-1,3,5-triazine

수율 97.6%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONare added, under nitrogen stream
2. 2
   기타at about 0° C
3. 3
   기타for 30 minutes
4. 4
   여과After filtration
5. 5
   세척washing with water to neutral pH
6. 6
   기타the resulting precipitate is dried

실험 절차

—400 ml of acetone cooled to 0° C. are added, under nitrogen stream, with 92.3 g of 2,4,6-trichloro-1,3,5-triazine, then with 38 g of tert-butylamine, always keeping the temperature at about 0° C. After keeping the resulting mixture at this temperature for 30 minutes, 66.7 g of a 30% NaOH aqueous solution, then 400 ml of water are dropped therein, and the resulting mixture is stirred for 1 hour at 0° C. After filtration and washing with water to neutral pH, the resulting precipitate is dried to obtain 108 g of 2-tert-butylamino-4,6-dichloro-1,3,5-triazine. M.p. 129-30° C.

출처