반응 #1142874

반응 방정식

compound

1-(2,2-Diethoxyethyl)-3-(pyrimidin-5-yl)-1H-pyrazole-5-amine

2-bromo-4-nitrotoluene

→

1-(2,2-Diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyrimidin-5-yl)-1H-pyrazole-5-amine

반응 조건

후처리

1. 1
   기타gave, after 3 h
2. 2
   온도of heating
3. 3
   온도under reflux
4. 4
   기타a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol)

실험 절차

Analogously to Example 13A/Step 1, 2.22 g (8.01 mmol) of the compound of Example 78A and 1.90 g (8.81 mmol) of 2-bromo-4-nitrotoluene gave, after 3 h of heating under reflux, a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol). This gave 1.93 g (49% of theory) of the title compound.

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