반응 #1142815

반응 방정식

compound

1-(2,2-Diethoxyethyl)-1′-(4-methoxybenzyl)-1H,1′H-3,4′-bipyrazol-5-amine

→

6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazole

용매

ethanol

sulphuric acid

반응 조건

후처리

1. 1
   기타The reaction was then purified directly by preparative HPLC (Method 11)
2. 2
   농축The product fractions were concentrated
3. 3
   기타the residue was dried under high vacuum

실험 절차

In a microwave oven (Biotage Initiator, with Dynamic Field Tuning), 155 mg (0.40 mmol) of the compound of Example 2A in 0.4 ml of ethanol and 0.2 ml of 2 M sulphuric acid were heated at 120° C. for 15 min. The reaction was then purified directly by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 54 mg (46% of theory) of the title compound.

출처