반응 #1141285

ord-6014722e39444eeab6e7833b2bcbe9b1

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Synthesized
  2. 2
    기타Crude product was purified by flash chromatography on silica-gel

실험 절차

Synthesized using compound 61b (760 mg, 4.49 mmol), NBS (878 mg, 4.93 mmol) and DBPO (54 mg, 0.23 mmol) in carbon tetrachloride according to Method A. Crude product was purified by flash chromatography on silica-gel using hexane/ethyl acetate (8:1) as eluent. White solid. Yield: 297 mg, 73%. 1H NMR (CDCl3, 500 MHz): δH (ppm)=4.54 (s, 2H), 7.42-7.53 (m, 3H), 7.71-7.77 (m, 1H), 7.80-7.85 (m, 1H), 7.98-8.04 (m, 2H), 8.72-8.76 (m, 1H); 13C NMR (CDCl3, 125 MHz): δC (ppm)=29.7, 120.6, 127.0, 128.4, 128.8, 130.1, 137.6, 138.5, 149.6, 157.36; (ESI): m/z=249.66 [M+H]+.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09394290B2uspto-grants-2016_07