반응 #11409

반응 방정식

ester

6-[(2-Benzylsulfanylbenzyl)ethylamino]Nicotinic Acid Methyl Ester

KOH

→

6-[(2-Benzylsulfanylbenzyl)ethylamino]Nicotinic Acid

용매

THF

H2O

반응 조건

후처리

1. 1
   농축concentrated
2. 2
   기타to remove THF
3. 3
   세척The aqueous phase was washed with ethyl ether
4. 4
   추출The acidified solution was extracted with Et2O or EtOAc (3X)
5. 5
   건조dried over MgSO4
6. 6
   여과filtered
7. 7
   농축concentrated in vacuo
8. 8
   기타to give a white solid

실험 절차

To a solution of the ester of Example 6 in THF (0.8 mL) was added a solution of KOH (14 mg, 0.255 mmol) in H2O (0.2 mL). The mixture was stirred at 50° C., then concentrated to remove THF. The aqueous phase was washed with ethyl ether, then the aqueous phase was acidified until pH 3–4 was reached. The acidified solution was extracted with Et2O or EtOAc (3X), dried over MgSO4, filtered and concentrated in vacuo to give a white solid.

출처