반응 #1140127

반응 방정식

(R)-naproxen

(+)-tramadol

→

(+)-tramadol (R)-naproxen

수율 61.5%

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타was evaporated
2. 2
   workup.WAITThe resulting solution was left
3. 3
   workup.WAITstanding at room temperature and after 24 hours
4. 4
   기타a solid had formed
5. 5
   여과The solid was filtered off
6. 6
   세척the filtrate was washed with 2 mL of methanol
7. 7
   기타dried under vacuum (10 mm Hg) for 4 hours

실험 절차

A solution of (R)-naproxen (925 mg, 4.02 mmol) in 3 mL of methanol was added to a solution of (+)-tramadol (530 mg, 2.01 mmol) in 1 mL of methanol. The mixture was stirred for 10 minutes and about half of the solvent was evaporated. The resulting solution was left standing at room temperature and after 24 hours a solid had formed. The solid was filtered off, the filtrate was washed with 2 mL of methanol and dried under vacuum (10 mm Hg) for 4 hours to give the methanol solvate of the 1:2 co-crystal of (+)-tramadol-(R)-naproxen as crystalline white needles (610 mg, 42%).

출처