반응 #1140124

반응 방정식

(S)-naproxen

(−)-tramadol

→

(−)-tramadol (S)-naproxen

수율 100.0%

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타the solvent was evaporated under vacuum
2. 2
   온도The oil was cooled to −197° C.
3. 3
   온도to warm to room temperature

실험 절차

A solution of (S)-naproxen (2.14 g, 9.3 mmol) in 20 mL of methanol was added in 10 minutes to a stirred solution of (−)-tramadol (2.45 g, 9.3 mmol) in 10 mL of methanol. The resulting solution was stirred at room temperature for 30 minutes and the solvent was evaporated under vacuum rendering a light yellow oil. The oil was cooled to −197° C. and allowed to warm to room temperature to give the amorphous (−)-tramadol-(S)-naproxen salt as a white solid (4.59 g, 100%).

출처