반응 #11381

반응 방정식

potassium carbonate

2-chloro-3-nitropyridine

cyclohexylamine

→

N-Cyclohexyl-3-nitro-2-pyridineamine

용매

DMF

반응 조건

후처리

1. 1
   추출The solution is then extracted with 200 ml of ether
2. 2
   세척the organic phase is washed three times with water
3. 3
   건조After drying over magnesium sulphate
4. 4
   기타the ether is evaporated off

실험 절차

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

출처