반응 #1137411

반응 방정식

(3R,3 aR)-3-((t-butyldimethylsiloxy)methyl)-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1(3H)-one

( a )

(3R,3aR)-3-((t-butyldimethylsiloxy)methyl)-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one

tetra-n-butylammonium fluoride

→

white solid

수율 64.3%

(3R,3aR)-3-(hydroxymethyl)-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one

수율 64.3%

반응 조건

후처리

1. 1
   기타materials, preparation

실험 절차

Using compound (3R,3 aR)-3-((t-butyldimethylsiloxy)methyl)-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1(3H)-one (0.597 g, 1.38 mmol) prepared above in (a), and tetra-n-butylammonium fluoride (1M, 2.8 ml) as starting materials, preparation following the method as described in Example 1 (b) afforded 0.283 g of white solid, yield 64.3%.

출처