반응 #1137402

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(3R,3 aS)-3-((t-butyldimethylsiloxy)methyl)-7-((R)-4-(t-butyldiphenylsiloxy)-2-oxopiperidin-1-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1(3H)-one

BCl3

dichloromethane

→

solid

수율 86.1%

(3R,3aS)-7-((R)-4-(t-butyldiphenylsiloxy)-2-oxopiperidin-1-yl)-3-(hydroxymethyl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one

수율 86.1%

용매

THF

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후처리

1. 1
   기타dried

실험 절차

Compound (3R,3 aS)-3-((t-butyldimethylsiloxy)methyl)-7-((R)-4-(t-butyldiphenylsiloxy)-2-oxopiperidin-1-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1(3H)-one (0.78 g, 1.135 mmol) was dissolved in THF. A solution of BCl3 in dichloromethane (1M, 6.81 ml, 6.81 mmol) was added, stirred at room temperature for 24 h, and dried by spinning. Column chromatography afforded pale yellow solid 0.56 g, yield 86.0%.

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