반응 #1136595

반응 방정식

sodium methoxide

3-cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2′-fluoro-5′-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoic acid

→

title compound

수율 94.6%

sodium 3-cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2′-fluoro-5′-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoate

수율 94.6%

용매

methanol

methanol

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure

실험 절차

A 28% solution of sodium methoxide (100 mg) in methanol was added to a solution of 3-cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2′-fluoro-5′-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoic acid (255 mg) in methanol (2.5 mL), and the mixture was stirred at room temperature for 5 min. The reaction mixture was concentrated under reduced pressure to give the title compound (252 mg) as a white amorphous solid.

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