반응 #1135841

반응 방정식

methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate

수율 67.7%

용매

toluene

반응 조건

후처리

1. 1
   농축concentrated
2. 2
   기타The residue was purified by biotage column chromatography

실험 절차

To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)

출처