반응 #1135840
ord-dcb05d37169b4b01acecedf154b74170
반응 방정식
N1-cyclopropylbenzene-1,2-diamine
triethylamine
methyl 8-chloro-8-oxooctanoate
→
methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate
수율 94.2%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with 1 N HCl, saturated sodium bicarbonate solution and brine
- 2농축The separated organic layer was concentrated
실험 절차
To a solution of N1-cyclopropylbenzene-1,2-diamine (221 mg, 1.49 mmol) and triethylamine (0.3 mL, 2.2 mmol) in DMF was added a solution of methyl 8-chloro-8-oxooctanoate (260 mg, 1.3 mmol) in DMF at 0° C. drop-wise. The reaction was stirred overnight at room temperature, diluted with ethyl acetate and washed with 1 N HCl, saturated sodium bicarbonate solution and brine. The separated organic layer was concentrated to give crude methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg)