반응 #1135839

반응 방정식

N-cyclopropyl-2-nitroaniline

ammonium formate

→

N1-cyclopropylbenzene-1,2-diamine

수율 97.4%

용매

methanol

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux under a nitrogen atmosphere overnight
3. 3
   여과filtered
4. 4
   농축The filtrate was concentrated
5. 5
   기타purified by biotage column chromatography

실험 절차

To a solution of N-cyclopropyl-2-nitroaniline (365 mg, 2.05 mmol) and ammonium formate (516 mg, 8.2 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give N1-cyclopropylbenzene-1,2-diamine (296 mg)

출처