반응 #1135835

반응 방정식

methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate

ammonium formate

→

methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate

수율 85.0%

용매

methanol

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux under a nitrogen atmosphere overnight
3. 3
   여과filtered
4. 4
   농축The filtrate was concentrated
5. 5
   기타purified by biotage column chromatography

실험 절차

To a solution of methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate (270 mg, 0.70 mmol) and ammonium formate (177 mg, 2.8 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (211 mg)

출처