반응 #1135833

반응 방정식

4-bromo-2-nitroaniline

phenylboronic acid

cesium carbonate

→

4-nitrobiphenyl-3-amine

수율 96.6%

용매

ethyleneglycol dimethyl ether

반응 조건

후처리

1. 1
   여과The mixture was filtered through a celite pad
2. 2
   농축The filtrate was concentrated
3. 3
   기타purified by biotage column chromatography

실험 절차

To a mixture of 4-bromo-2-nitroaniline (217 mg, 1.0 mmol), phenylboronic acid (122 mg, 1.0 mmol), tetrakis-(triphenylphosphine)palladium (55 mg, 0.05 mmol) and cesium carbonate (650 mg, 2.0 mmol) was added 3 mL of ethyleneglycol dimethyl ether (DME). The reaction was heated to 80° C. and stirred under nitrogen atmosphere overnight. The mixture was filtered through a celite pad. The filtrate was concentrated and purified by biotage column chromatography to give 4-nitrobiphenyl-3-amine (207 mg)

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