반응 #1135828

반응 방정식

Acetic acid 3-(3,4-dimethoxy-phenyl)-8-methyl-4-oxo-chroman-7-yl ester

imidazole

H2O

→

3-(3,4-Dimethoxy-phenyl)-7-hydroxy-8-methyl-chroman-4-one

용매

EtOH

반응 조건

후처리

1. 1
   workup.ADDITIONbefore pouring
2. 2
   여과A fine white precipitate was filtered off

실험 절차

Acetic acid 3-(3,4-dimethoxy-phenyl)-8-methyl-4-oxo-chroman-7-yl ester (1.1 g, 3.2 mmol) and imidazole (3.2 g, 47 mmol) were refluxed in EtOH (100 ml). The reaction was complete after 90 minutes and allowed to cool to room temperature before pouring into stirred H2O (800 ml). A fine white precipitate was filtered off and 1H NMR in d-CDCl3 indicated the solid was 3-(3,4-Dimethoxy-phenyl)-7-hydroxy-8-methyl-chroman-4-one in >95% purity (0.31 g, 30%).

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