반응 #1135820

반응 방정식

methyl laurate

dimethylaminobutanol

→

3-dimethylaminopropyl laurate

수율 67.0%

반응 조건

후처리

1. 1
   기타A syringe was inserted
2. 2
   기타through the cap
3. 3
   기타Nitrogen was bubbled at a rate sufficient
4. 4
   workup.ADDITIONto mix the contents
5. 5
   기타set to 65° C
6. 6
   온도to cool
7. 7
   기타The Novozym 435 was removed by filtration
8. 8
   기타to afford the product as a pale, yellow oil (9.2 g; 67% yield)
9. 9
   기타without further purification

실험 절차

To a 50-mL conical bottom plastic vial was added methyl laurate (38.5 mmol), dimethylaminobutanol (46.2 mmol, 1.2 eq), and Novozym 435 (400 mg). A syringe was inserted through the cap and two additional holes were punched for gas to exit. Nitrogen was bubbled at a rate sufficient to mix the contents. The vial was placed in a heating block set to 65° C. The reaction was monitored by GC/MS to observe the disappearance of starting material. The reaction was complete after approximately 24 hours. The reaction mixture was allowed to cool. The Novozym 435 was removed by filtration to afford the product as a pale, yellow oil (9.2 g; 67% yield) without further purification.

출처