반응 #1135812

반응 방정식

2-methyl-3-nitrophenol

iodoethane

potassium carbonate

→

1-ethoxy-2-methyl-3-nitrobenzene

수율 100.7%

용매

acetone

반응 조건

후처리

1. 1
   온도with heating
2. 2
   온도under reflux for ten hours
3. 3
   여과filtered
4. 4
   농축the resulting filtrates were concentrated
5. 5
   추출The resulting mixtures were extracted with ethyl acetate
6. 6
   세척the organic layers were washed with water and saturated saline
7. 7
   건조were dried over anhydrous magnesium sulfate
8. 8
   농축were then concentrated under reduced pressure

실험 절차

A mixture of 2-methyl-3-nitrophenol 33.5 g, iodoethane 41 g and potassium carbonate 90 g in acetone 400 mL was stirred with heating under reflux for ten hours. The mixtures were cooled to room temperature and filtered and the resulting filtrates were concentrated. The resulting mixtures were extracted with ethyl acetate and the organic layers were washed with water and saturated saline, and were dried over anhydrous magnesium sulfate and were then concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give 1-ethoxy-2-methyl-3-nitrobenzene 39.9 g.

출처