반응 #1135805

반응 방정식

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타To the reaction mixtures
2. 2
   추출the mixtures were extracted with ethyl acetate
3. 3
   세척The organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   건조were dried over anhydrous sodium sulfate
5. 5
   농축The resulting mixtures were concentrated under reduced pressure

실험 절차

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

출처