반응 #1135800

반응 방정식

1-bromo-2-methyl-3-aminobenzene

triphosgene

→

1-bromo-3-isocyanato-2-methylbenzene

수율 106.3%

용매

toluene

반응 조건

후처리

1. 1
   온도with heating
2. 2
   온도under reflux for three hours
3. 3
   온도to cool
4. 4
   농축were concentrated under reduced pressure

실험 절차

A mixture of 1-bromo-2-methyl-3-aminobenzene 25.0 g, triphosgene 60.0 g and toluene 400 mL was stirred with heating under reflux for three hours. The reaction mixtures after standing to cool were concentrated under reduced pressure to give 1-bromo-3-isocyanato-2-methylbenzene 30.3 g.

출처