반응 #1135797

반응 방정식

methyl chloroformate

tetrahydrofuran

1-chloro-2-methyl-3-aminobenzene

→

1-chloro-2-methyl-3-methoxycarbonylaminobenzene

용매

water

반응 조건

후처리

1. 1
   기타To the reaction mixtures
2. 2
   추출the resulting mixtures were extracted with ethyl acetate
3. 3
   세척The organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   건조were dried over anhydrous sodium sulfate
5. 5
   농축The mixtures were concentrated under reduced pressure

실험 절차

Under cooling, to a mixture of methyl chloroformate 30 mL and tetrahydrofuran 50 mL was added dropwise 1-chloro-2-methyl-3-aminobenzene 5.00 g and the mixtures were stirred at 25° C. for a half hour. To the reaction mixtures was added water and the resulting mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The mixtures were concentrated under reduced pressure to give 1-chloro-2-methyl-3-methoxycarbonylaminobenzene 5.80 g.

출처