반응 #1133149

반응 방정식

8-[(2,5-dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one

1-(difluoromethyl)-3-methyl-pyrazol-4-amine

→

desired product

8-[[5-chloro-2-[[1-(difluoromethyl)-3-methyl-pyrazol-4-yl]amino]-4-pyridyl]amino]-2-methyl-3,4-dihydroisoquinolin-1-one

반응 조건

후처리

1. 1
   기타Column chromatography (SiO2, 50 equiv.; 50:50; EtOAc:MeOH) followed by re-crystallisation
2. 2
   온도from warm MeOH (1-2 mL)

실험 절차

This compound was prepared from 8-[(2,5-dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one and 1-(difluoromethyl)-3-methyl-pyrazol-4-amine. Column chromatography (SiO2, 50 equiv.; 50:50; EtOAc:MeOH) followed by re-crystallisation from warm MeOH (1-2 mL) furnished 64 mg of the desired product.

출처