반응 #11309

반응 방정식

3-phenylcyclohex-2-enone

potassium cyanide

trimethylamine hydrochloride

sodium bicarbonate

→

3-oxo-1-phenylcyclohexanecarbonitrile

수율 92.0%

용매

H2O

DMF

반응 조건

후처리

1. 1
   온도After cooling down to room temperature
2. 2
   기타the organic layer was separated
3. 3
   추출The aqueous layer was extracted with diethyl ether 3 times
4. 4
   세척The combined organic layers were washed with saturated sodium chloride solution
5. 5
   건조dried over magnesium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated under vacuum

실험 절차

A mixture of 3-phenylcyclohex-2-enone (14.3 mmol), potassium cyanide (1.92 g) and trimethylamine hydrochloride (2.06 g, 21.5 mmol) in H2O (10 mL) and DMF (57 mL) was heated at 93° C. for 6 hr. After cooling down to room temperature, saturated sodium bicarbonate was added and the organic layer was separated. The aqueous layer was extracted with diethyl ether 3 times. The combined organic layers were washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated under vacuum to get 2.62 g of the crude 3-oxo-1-phenylcyclohexanecarbonitrile which was directly taken to the next step without further purification.

출처