반응 #11297

반응 방정식

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

용매

water

acetone

ethyl acetate

반응 조건

후처리

1. 1
   온도The reaction was refluxed under nitrogen
2. 2
   온도After 5–6 hours of reflux
3. 3
   기타the organic layer was separated
4. 4
   건조dried over magnesium sulfate
5. 5
   기타evaporated to dryness
6. 6
   기타to afford a white fluffy powder

실험 절차

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

출처