반응 #11264
ord-3a88dd9b299e453abb8cca072f727e81
반응 방정식
phosphorus oxychloride
ethylacetoacetate
cyanoacetamide
→
3-cyano-2,5-dihydroxy-4-methylpyridine
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).