반응 #1124855

반응 방정식

2-bromo-3-methoxy-pyridine

tributyl(1-ethoxyvinyl)tin

→

2-(1-ethoxy-vinyl)-3-methoxy-pyridine

수율 84.3%

용매

DMF

반응 조건

후처리

1. 1
   기타Flush with N2
2. 2
   기타seal
3. 3
   기타Purify the mixture by flash chromatography on silica gel eluting with 0-30% EtOAc/hexanes

실험 절차

Add copper (I) iodide (38 mg, 0.2 mmol) to a mixture of 2-bromo-3-methoxy-pyridine (188 mg, 1.0 mmol), tributyl(1-ethoxyvinyl)tin (0.68 mL, 2.0 mmol), and DMF (anhydrous, 4 mL) in a sealed tube. Flush with N2, seal, heat at 80° C. for 3 h. Purify the mixture by flash chromatography on silica gel eluting with 0-30% EtOAc/hexanes to afford 2-(1-ethoxy-vinyl)-3-methoxy-pyridine (151 mg, 84%).

출처