반응 #1124

반응 방정식

hydrochloric acid

2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

sodium methoxide

water

→

2-Methoxy-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

용매

dimethylformamide

methanol

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   추출the reaction product is extracted with ethyl acetate
3. 3
   기타For purification it
4. 4
   기타is chromatographed

실험 절차

2.21 g (6.04 mmol) of 2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine in 30 ml of dimethylformamide are treated with 4.31 ml of 30% strength solution of sodium methoxide in methanol and the mixture is heated at 80° C. for 1 hour. After cooling, water is added, the mixture is adjusted to pH 8 using 1/2 conc. hydrochloric acid and the reaction product is extracted with ethyl acetate. For purification it is chromatographed. Yield: 1.72 g (79%); Rf =0.4 (diisopropyl ether)

출처