반응 #1121744

반응 방정식

compound ( 1 )

Boc-Thr-Gly-OEt

sodium hydroxide

hydrochloric acid

→

Boc-Thr-Gly-OH

수율 60.2%

용매

methanol

반응 조건

후처리

1. 1
   기타the mixture was reacted at room temperature for 3 hours
2. 2
   기타After completion of the reaction
3. 3
   추출was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3)
4. 4
   농축The extracted objective substance was concentrated under reduced pressure
5. 5
   기타dried

실험 절차

The obtained compound (1) (10.0 g, 33 mmol) was dissolved in methanol (150 mL), and 1 N aqueous sodium hydroxide (33 mL, 33 mmol) was further added thereto, and then the mixture was reacted at room temperature for 3 hours with stirring. After completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid, and objective substance was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3). The extracted objective substance was concentrated under reduced pressure and dried, to obtain Boc-Thr-Gly-OH (2) (5.4 g) (yield; 60.2%).

출처