반응 #1121724

반응 방정식

ethyl 4-bromobutanoate

1-methylpiperazine

K2CO3

→

ethyl 4-(4-methylpiperzin-1-yl)butanoate

수율 96.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was refluxed for 18 h
2. 2
   농축before concentrated in vacuo
3. 3
   기타The organic layer was then separated
4. 4
   추출the aqueous layer was extracted with dichloromethane (DCM, 3×150 mL)
5. 5
   세척The combined organic extracts were washed with water (150 mL)
6. 6
   건조dried (Na2SO4)
7. 7
   농축concentrated in vacuo

실험 절차

A mixture of ethyl 4-bromobutanoate (5.75 g, 29.5 mmol; Aldrich No. 167118) and 1-methylpiperazine (3.55 mL, 32.0 mmol; Aldrich No. 130001) and anhydrous K2CO3 (4.5 g, 32.5 mmol; Fisher No. P208) in acetonitrile (MeCN, 150 mL) was refluxed for 18 h before concentrated in vacuo. The organic layer was then separated and the aqueous layer was extracted with dichloromethane (DCM, 3×150 mL). The combined organic extracts were washed with water (150 mL), dried (Na2SO4), and concentrated in vacuo to give ethyl 4-(4-methylpiperzin-1-yl)butanoate (6.01 g, 96%) as a yellow oil.

출처