반응 #1121718

반응 방정식

acetophenone

4-tert-butylbenzoyl chloride

→

1-phenylvinyl 4-tert-butylbenzoate

수율 57.0%

용매

water

반응 조건

후처리

1. 1
   workup.WAITThe mixture was then left
2. 2
   온도to cool
3. 3
   추출extracted with dichloromethane
4. 4
   건조The organic phase was dried over magnesium sulfate
5. 5
   기타the solvent was removed under reduced pressure
6. 6
   기타A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1)

실험 절차

A mixture of 4.16 g (21.62 mmol) of acetophenone trimethylsilylenol, 4.33 g (22.01 mmol) of 4-tert-butylbenzoyl chloride and 136 mg of mercuric chloride was heated at 100° C. for 2 h. The mixture was then left to cool, water was added over the reaction crude and extracted with dichloromethane. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1) giving 1.17 g of 1-phenylvinyl 4-tert-butylbenzoate. Yield 57%.

출처