반응 #1121716

반응 방정식

hydroquinone

1,6-dibromo hexane

Potassium hydroxide

→

4-(6-bromohexyloxy)phenol

수율 39.4%

용매

methanol

반응 조건

후처리

1. 1
   기타fluxed at 60° C.
2. 2
   기타(Celsius) overnight
3. 3
   기타is lowered to a room temperature
4. 4
   기타methanol was evaporated from the reaction mixture
5. 5
   추출Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters))
6. 6
   기타Water was removed over magnesium sulfate
7. 7
   기타the solvents were evaporated
8. 8
   기타the resulting reaction mixture
9. 9
   기타was purified

실험 절차

As shown in the following Scheme, hydroquinone (1) (4.5 g (grams)) and 1,6-dibromo hexane (2) (10 g (grams)) were dissolved in methanol (100 ml (milliliters)) at a room temperature. Potassium hydroxide (2.3 g (grams)) was added to the resulting mixture solution, and then fluxed at 60° C. (Celsius) overnight. Next day, the temperature of the reaction mixture is lowered to a room temperature, and methanol was evaporated from the reaction mixture. Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters)). Water was removed over magnesium sulfate, and the solvents were evaporated, and the resulting reaction mixture was purified using a column chromatography (developer solution: ethylacetate/hexane=1/5 volume ratio) to obtain 4.4 g (grams) of 4-(6-bromohexyloxy)phenol (3).

출처