반응 #1119227

반응 방정식

Sodium pyruvate

anisaldehyde

→

4-(p-Methoxyphenyl)-2-Oxo-3-Butenoic Acid

용매

sodium hydroxide

반응 조건

후처리

1. 1
   workup.WAITThe solution was aged twenty-four hours at 20° C.
2. 2
   온도while maintaining a temperature of 0° C
3. 3
   추출The 4-(p-methoxyphenyl)-2-oxo-3-butenoic acid product was then extracted with 500 ml ethyl acetate
4. 4
   기타isolated as a yellow solid by concentration under vacuum
5. 5
   기타The yield by HPLC analysis

실험 절차

Sodium pyruvate (24.2 g, 0.22 mol) was dissolved in 200 ml 1N aqueous sodium hydroxide at 20° C. To this solution there was added anisaldehyde (27.4 g, 0.20 mol) at 0.2 ml/min. The solution was aged twenty-four hours at 20° C., cooled at 0° C. and acidified with 6N NCl to pH 1.0 while maintaining a temperature of 0° C. The 4-(p-methoxyphenyl)-2-oxo-3-butenoic acid product was then extracted with 500 ml ethyl acetate and isolated as a yellow solid by concentration under vacuum. The yield by HPLC analysis was 88%.

출처